The Yekaterinburg Museum of Fine Arts, established in 1986, is the largest art museum of the Urals region of Russia. It is based in Voevodina Street on the banks of the Iset River in the city of Yekaterinburg (known as Sverdlovsk between 1924 and 1991 and the fourth largest city in Russia).

At the heart of the museum building is one of the oldest buildings in Yekaterinburg, a hospital built in 1730 for the Yekaterinburg Ironworks.