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english.stackexchange.com how-did-the-phrase-are-you-nuts-come-about
Etymology Online contends that nuts was influenced by the metaphoric application of nut to refer to one's head. To be off one's nut dates from 1861 as an expression for "to be insane". Similarly, one could say "to be out of mind" or "to be out of one's head". In British English, a crazy person is a nutter (possibly antiquated). Also of note: nuts to mean "crazy" predates the usage of the same to mean testicles (1846 and 1915, respectively).