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Prof. Dr. Aysun ve Prof. Dr. Sibel Canbazkaba (Zumlupınar Üniversitesi Tıp Fakültesi Nöroloji Bilim Dalı) konuşmacılar olarak yer almaktadır.","Video, multiple skleroz (MS) hastalığının immün patogenezini detaylı şekilde ele almaktadır. MS'nin 20-40 yaş aralığında görülen, santral sinir sisteminin otoimmün hastalıklarından biri olduğu, kronik inflamatuar deza ve nöro-dejeneratif bir süreç olduğu açıklanmaktadır. Sunumda MS'nin patolojik özellikleri, genetik ve çevresel faktörlerin rolü, kan-beyin bariyeri, T hücreleri ve B hücrelerinin rolü gibi konular detaylı olarak anlatılmaktadır.","Konuşmacı ayrıca mikroglialar, astrositler ve B hücrelerinin hastalığın gelişimindeki rolleri, lenfatik drenaj sisteminin önemi ve son yıllarda yapılan moleküler çalışmalar hakkında bilgiler vermektedir. MS'nin kesin bir tedavisi bulunmadığı ve hastalığın patogenezini iyi anlamak için farklı mekanizmaların incelenmesi gerektiği vurgulanmaktadır."]},"endTime":1261,"title":"Multiple Skleroz'da Immün Patogenezi","beginTime":0}],"fullResult":[{"index":0,"title":"Multible Skleroz'un Tanımı ve Patogenezi","list":{"type":"unordered","items":["Multible skleroz (MS), 20-40 yaş arasında görülen, en sık karşılaşılan santral sinir sisteminin otoimmün hastalıklarından biri ve en fazla bırakan bir hastalıktır.","MS'nin kesin nedeni ve hastadan hastaya değişip değişmediği hala anlaşılmaz, ancak genetik olarak duyarlı bireylerde stoklastik olarak ve çevresel faktörlerin de ortaya çıktığı bir otoimmün süreçtir.","Genetik varyasyon hastalık riskinin yaklaşık %30'unu oluştururken, genetik olmayan faktörler imnolojik heterojeni genetik faktörlerden çok daha büyük katkılar 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vardır."]},"beginTime":324,"endTime":444,"href":"/video/preview/12190995433479056458?parent-reqid=1774208400991961-5168868821750020120-balancer-l7leveler-kubr-yp-klg-120-BAL&text=MsSkinyMaple&t=324&ask_summarization=1"},{"index":3,"title":"Kan-Beyin Bariyeri ve Bağışıklık Sistemi","list":{"type":"unordered","items":["İlk yıllarda santral sinir sisteminin imtiyazlı bir bölge olduğu ve kan-beyin bariyerinin immün pervilige bölge olarak kabul edildiği teorisi vardı.","1979'da Primias'ın ortaya attığı ve 2015'te yenilenen bilgiler, beynin lenfatik drenajının immün regülasyona katkıda bulunduğu ve santral sinir sistemi immün hücrelerin bu yoldan çok daha kolay girip çıktığı kanıtlamıştır.","Meningeal, perivasküler ve periventriküler boşluklardaki kandan üreyen doğal bağışıklık hücreleri, boss aracılığıyla devriye gezen T hücrelerine antijen sunmak için uygun bir şekilde kompartmantalize oluyor."]},"beginTime":444,"endTime":613,"href":"/video/preview/12190995433479056458?parent-reqid=1774208400991961-5168868821750020120-balancer-l7leveler-kubr-yp-klg-120-BAL&text=MsSkinyMaple&t=444&ask_summarization=1"},{"index":4,"title":"Otoaktif T Hücreler ve İmmün Kaskatı","list":{"type":"unordered","items":["Otoaktif T hücrelerinin çoğu sağlıklı bireylerde silinirken, otoimmün hastalıklarda bu işlem kusurlu olup bazı otoaktif hücreleri perifere savunuyor.","Otoimmün hastalıklarda tolerans kırılırsa, regülatör T hücrelerin fonksiyonları bozulabiliyor, azalıyor veya sayıları değişebiliyor.","Aktive olduktan sonra CD8 T hücreleri, farklılaşmış CD4 T hücreleri ve T-helper-17'ler, B hücreleri ve doğal bağışıklık hücreleri kan-beyin bariyerini aşarak parenk içerisinde iltihaplanma ve doku hasarına yol 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